Selected Publications

TAM receptors in phagocytosis: Beyond the mere internalization of particles.

Immunol Rev. 2023 Oct;319(1):7-26. doi: 10.1111/imr.13267. Epub 2023 Aug 19.

Phagocytosis in the retina promotes local insulin produvtion in the eye.

Etchegaray JI, Kelley S, Penberthy K, Karvelyte L, Nagasaka Y, Gasperino S, Paul S, Vikram Seshadri V, Raymond M, Marco AN, Pinney J, tremska M, Barron B, Lucas C, Wase N, Fan Y, Unanue E, Kundu B, Burstyn-Cohen T, Perry J, Ambati J, Ravichandran KS.

Nat Metab. 2023 Feb;5(2):207-218. doi: 10.1038/s42255-022-00728-0. Epub 2023 Feb 2.

Regulation of bone homeostasis by MERTK and TYRO3.

Engelmann J, Zarrer J, Gensch V, Riecken K, Berenbrok N, Luu TV, Beitzen-Heineke A, Vargas-Delgado ME, Pantel K, Bokemeyer C, Bhamidipati S, Darwish IS, Masuda E, Burstyn-Cohen T, Alberto EJ, Ghosh S, Rothlin C, Hesse E, Taipaleenmäki H, Ben-Batalla I, Loges S.

Nat Commun 2022 Dec 12;13(1):7689 DOI: 10.1038/s41467-022-33938-x

TAM Signaling in the Nervous System.
Burstyn-Cohen T, Hochberg A. Brain Plast. 2021 Aug 23;7(1):33-46. doi: 10.3233/BPL-210125. eCollection 2021.PMID: 34631419 Free PMC article
From Bite to Byte: Dental Structures Resolved at a Single-Cell Resolution.
Fresia R, Marangoni P, Burstyn-Cohen T, Sharir A. J Dent Res. 2021 Aug;100(9):897-905. doi: 10.1177/00220345211001848. Epub 2021 Mar 25.PMID: 33764175 Free PMC article. Review.
Myeloid cell-derived PROS1 inhibits tumor metastasis by regulating inflammatory and immune responses via IL-10.
Maimon A, Levi-Yahid V, Ben-Meir K, Halpern A, Talmi Z, Priya S, Mizraji G, Mistriel-Zerbib S, Berger M, Baniyash M, Loges S, Burstyn-Cohen T. J Clin Invest. 2021 May 17;131(10):e126089. doi: 10.1172/JCI126089.PMID: 33848267 Free PMC article.
TAM receptors, Phosphatidylserine, inflammation, and Cancer.
Burstyn-Cohen T, Maimon A. Cell Commun Signal. 2019 Nov 27;17(1):156. doi: 10.1186/s12964-019-0461-0.PMID: 31775787
Inhibition of MERTK Promotes Suppression of Tumor Growth in BRAF Mutant and BRAF Wild-Type Melanoma. Sinik L, Minson KA, Tentler JJ, Carrico J, Bagby SM, Robinson WA, Kami R, Burstyn-Cohen T, Eckhardt SG, Wang X, Frye SV, Earp HS, DeRyckere D, Graham DK. Mol Cancer Ther. 2019 Feb;18(2):278-288. doi: 10.1158/1535-7163.MCT-18-0456. Epub 2018 Nov 27. PMID: 30482852
Cell-intrinsic regulation of murine epidermal Langerhans cells by protein S.
Tabib Y, Jaber NS, Nassar M, Capucha T, Mizraji G, Nir T, Koren N, Aizenbud I, Maimon A, Eli-Berchoer L, Wilensky A, Burstyn-Cohen T, Hovav AH. Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):E5736-E5745. doi: 10.1073/pnas.1800303115. Epub 2018 Jun 5.
PMID: 29871951
Multiple Regulatory Levels of Growth Arrest-Specific 6 in Mucosal Immunity Against an Oral Pathogen.
Nassar M, Tabib Y, Capucha T, Mizraji G, Nir T, Saba F, Salameh R, Eli-Berchoer L, Wilensky A, Burstyn-Cohen T, Hovav AH.
Front Immunol. 2018 Jun 18;9:1374. doi: 10.3389/fimmu.2018.01374. eCollection 2018. PMID:29967614
Macrophage-Derived Protein S Facilitates Apoptotic Polymorphonuclear Cell Clearance by Resolution Phase Macrophages and Supports Their Reprogramming.
Lumbroso D, Soboh S, Maimon A, Schif-Zuck S, Ariel A, Burstyn-Cohen T.
Front Immunol. 2018 Mar 1;9:358. doi: 10.3389/fimmu.2018.00358. eCollection 2018. PMID:29545796
TAM receptor signaling in development.
Burstyn-Cohen T. Int J Dev Biol. 2017;61(3-4-5):215-224. doi: 10.1387/ijdb.160285tb. Review. PMID: 28621419
Protein S Negatively Regulates Neural Stem Cell Self-Renewal through Bmi-1 Signaling.
Zelentsova K, Talmi Z, Abboud-Jarrous G, Capucha T, Sapir T, Burstyn-Cohen T.Front Mol Neurosci. (2017) May 2; 00124.
Protein S drives Oral Squamous Cell Carcinoma Tumorigenicity through regulation of AXL.
Abboud-Jarrous G, Priya S, MAimon A, Fischman S, Cohen-Elisha M, Czerninski R, Burstyn-Cohen T. Oncotarget. (2017) 8:13986-14002.
Protein S Regulates Neural Stem Cell Quiescence and Neurogenesis.
Zelentsova K, Talmi Z, Abboud-Jarrous G, Sapir T, Capucha T, Nassar M, Burstyn-Cohen T. Stem Cells. 2016 Oct 18.
GAS6 is a key homeostatic immunological regulator of host-commensal interactions in the oral mucosa.
Nassar M, Tabib Y, Capucha T, Mizraji G, Nir T, Pevsner-Fischer M, Zilberman-Schapira G, Heyman O, Nussbaum G, Bercovier H, Wilensky A, Elinav E, Burstyn-Cohen T, Hovav AH. Proc Natl Acad Sci U S A. 2017 Jan 3.
Genetic dissection of TAM receptor-ligand interaction in retinal pigment epithelial cell phagocytosis.
Burstyn-Cohen T, Lew ED, Través PG, Burrola PG, Hash JC, Lemke G. Neuron. 2012 Dec 20;76(6):1123-32.
Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis.
Burstyn-Cohen, T., Heeb, M-J. and Lemke, G. J. Clin. Ivest. (2009) 119 (10) 2942-2953.
TAM Receptors and the Clearance of Apoptotic Cells.
Lemke, G. and Burstyn-Cohen, T. (2010) Ann. N.Y.Acad. Sci. 1209(1)23-29. Ann N Y Acad Sci. 2010 Oct;1209:23-9.
TAM receptor function in the retinal pigment epithelium.
Prasad, D., Rothlin, C.V., Burrola, P., Burstyn-Cohen, T., Lu, X., de Frutos, P. G. and Lemke, G. (2006) Mol. Cell. Nurosc. 33(1) 96-108.

Collaborations & Previous Work

Programming asynchronous replication in stem cells.
Masika H, Farago M, Hecht M, Condiotti R, Makedonski K, Buganim Y, Burstyn-Cohen T, Bergman Y, Cedar H.
Nat Struct Mol Biol. 2017 Dec;24(12):1132-1138. doi: 10.1038/nsmb.3503. Epub 2017 Nov 13. PMID: 29131141

Retinal Phenotype following Combined Deletion of the Chemokine Receptor CCR2 and the Chemokine CX3CL1 in Mice.
Hagbi-Levi S, Grunin M, Elbaz-Hayoun S, Tal D, Obolensky A, Hanhart J, Banin E, Burstyn-Cohen T, Chowers I. Ophthalmic Res. 2016;55(3):126-34.

Alzheimer’s disease-causing proline substitutions lead to presenilin 1 aggregation and malfunction.
Ben-Gedalya T, Moll L, Bejerano-Sagie M, Frere S, Cabral WA, Friedmann-Morvinski D, Slutsky I, Burstyn-Cohen T, Marini JC, Cohen E. EMBO J. 2015 Nov 12;34(22):2820-39.

Distinct Murine Mucosal Langerhans Cell Subsets Develop from Pre-dendritic Cells and Monocytes.
Capucha T, Mizraji G, Segev H, Blecher-Gonen R, Winter D, Khalaileh A, Tabib Y, Attal T, Nassar M, Zelentsova K, Kisos H, Zenke M, Seré K, Hieronymus T, Burstyn-Cohen T, Amit I, Wilensky A, Hovav AH. Immunity. 2015 Aug 18;43(2):369-81.

T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response.
Carrera Silva EA, Chan PY, Joannas L, Errasti AE, Gagliani N, Bosurgi L, Jabbour M, Perry A, Smith-Chakmakova F, Mucida D, Cheroutre H, Burstyn-Cohen T, Leighton JA, Lemke G, Ghosh S, Rothlin CV. Immunity. 2013 Jul 25;39(1):160-70.

Disturbed distribution of proliferative brain cells during lupus-like disease.
Stanojcic M, Burstyn-Cohen T, Nashi N, Lemke G, Sakic B. Brain Behav Immun. 2009 Oct;23(7):1003-13.

Chemokine receptor expression in peripheral blood monocytes from patients with neovascular age-related macular degeneration.
Grunin M, Burstyn-Cohen T, Hagbi-Levi S, Peled A, Chowers I. Invest Ophthalmol Vis Sci. 2012 Aug 7;53(9):5292-300.

Actin enables the antimicrobial action of LL-37 peptide in the presence of microbial proteases.
Sol A, Skvirsky Y, Nashef R, Zelentsova K, Burstyn-Cohen T, Blotnick E, Muhlrad A, Bachrach G. J Biol Chem. 2014 Aug 15;289(33):22926-41.

Association of pattern dystrophy with an HTRA1 single-nucleotide polymorphism.
Jaouni T, Averbukh E, Burstyn-Cohen T, Grunin M, Banin E, Sharon D, Chowers I. Arch Ophthalmol. 2012 Aug;130(8):987-91.

Reduced IGF-1 signaling delays age-associated proteotoxicity in mice.
Cohen E, Paulsson JF, Blinder P, Burstyn-Cohen T, Du D, Estepa G, Adame A, Pham HM, Holzenberger M, Kelly JW, Masliah E, Dillin A. Cell. 2009 Dec 11;139(6):1157-69.

Reduced IGF-1 signaling delays age-associated proteotoxicity in mice.
Cohen E, Paulsson JF, Blinder P, Burstyn-Cohen T, Du D, Estepa G, Adame A, Pham HM, Holzenberger M, Kelly JW, Masliah E, Dillin A. Cell. 2009 Dec 11;139(6):1157-69.

Early stages of neural crest ontogeny: formation and regulation of cell delamination.
Kalcheim C, Burstyn-Cohen T. Int J Dev Biol. 2005;49(2-3):105-16.

Canonical Wnt activity regulates trunk neural crest delamination linking BMP/noggin signaling with G1/S transition.
Burstyn-Cohen T, Stanleigh J, Sela-Donenfeld D, Kalcheim C. Development. 2004 Nov;131(21):5327-39.

Association between the cell cycle and neural crest delamination through specific regulation of G1/S transition.
Burstyn-Cohen T, Kalcheim C. Dev Cell. 2002 Sep;3(3):383-95.

F-spondin is a contact-repellent molecule for embryonic motor neurons.
Tzarfati-Majar V, Burstyn-Cohen T, Klar A. Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4722-7.

F-spondin and mindin: two structurally and functionally related genes expressed in the hippocampus that promote outgrowth of embryonic hippocampal neurons.
Feinstein Y, Borrell V, Garcia C, Burstyn-Cohen T, Tzarfaty V, Frumkin A, Nose A, Okamoto H, Higashijima S, Soriano E, Klar A. Development. 1999 Aug;126(16):3637-48.

F-Spondin is required for accurate pathfinding of commissural axons at the floor plate.
Burstyn-Cohen T, Tzarfaty V, Frumkin A, Feinstein Y, Stoeckli E, Klar A. Neuron. 1999 Jun;23(2):233-46.

F-Spondin, expressed in somite regions avoided by neural crest cells, mediates inhibition of distinct somite domains to neural crest migration.
Debby-Brafman A, Burstyn-Cohen T, Klar A, Kalcheim C. Neuron. 1999 Mar;22(3):475-88.

Accumulation of F-spondin in injured peripheral nerve promotes the outgrowth of sensory axons.
Burstyn-Cohen T, Frumkin A, Xu YT, Scherer SS, Klar A. J Neurosci. 1998 Nov 1;18(21):8875-85.

Contact Information

talbu@mail.huji.ac.il | Tel (Office): +972-2-675-8582

Institue of Biomedical and Oral Research (IBOR),

Faculty of Dental Medicine, the Hebrew University, Jerusalem