Our lab is interested in understanding the molecular and cellular mechanisms that underlie tissue homeostasis in health and in disease. We investigate the role of TAM receptors and their agonists Protein S and Gas6 in development and throughout adulthood. We combine biochemical, cell-biological and genetically engineered mouse model approaches. Tyro3, Axl, and MerTK comprise the TAM family of receptor tyrosine kinases. Together with their ligands Gas6 and Protein S (PROS1) TAM signaling plays a key role in maintaining a healthy balance in various physiological systems, including the endothelial, nervous, immune and reproductive systems. Several human diseases are associated with the dysregulation of TAM signaling and its components, including blood hypercoagulation, inflammation, cancer, autoimmune disease and blindness. We focus on the role of PROS1 as a TAM ligand in various physiological settings, to understand how PROS1-mediated TAM signaling is critical to homeostatic regulation. Specific projects in the lab focus on the developing and adult nervous system, the vascular system, in vision and in cancers. continue..